Scientists Found Triggering Factor Blood Clots with AstraZeneca Jab
Vaccine-Induced Immune Thrombotic Thrombocytopenia Has Caused the Death Of 73 Individuals in The United Kingdom
It is being believed by scientists in various areas of the world that they have been able to find out the triggering factor that has led towards the extremely rare form of blood clots after the administration of the AstraZeneca coronavirus vaccine this year. The team of researchers, present in the United States and Cardiff, have been able to provide an exquisite number of details regarding the process that occurs in the body and later forms life-threatening blood clots.
It has been found out that a protein present in the bloodstream is attracted to a specific key component that is in the administered vaccine. The scientists think that this then starts a chain reaction, which also involves the immunological system of the body, and can culminate in multiple dangerous blood clots that increase the chances of a sudden life-threatening condition.
The AstraZeneca vaccine against the coronavirus infection is thought to have been able to save the lives of millions of individuals in various regions of the world.
However, several concerns have been raised regarding the sudden formation of rare blood clots, which has shaped the usage of the vaccine across the world, including an alternate Covid-19 vaccine offering to individuals that are under the age of 40. Due to this reason, a scientific hunt had also begun to be able to figure out the main cause due to which the blood clots are forming inside the body and measures that should be taken to prevent such conditions.
The scientists working at the pharmaceutical firm AstraZeneca had also joined to provide their insight into the research after they had published their initial results regarding the vaccine. A spokesperson for the firm AstraZeneca said that the blood clots that are rarely being formed after the individuals had been administered with their vaccine have likely occurred due to the coronavirus infection, rather than the vaccine itself while a complete statement regarding the cause is yet to be established.
She further added that although the current research has not given a definitive answer, it has still offered insight regarding the probable cause for the formation of blood clots in rare cases, while the firm is currently exploring different ways through which they would be able to utilize these findings to remove this rare side effect of coronavirus vaccine.
Probable link for blood clots
There had been two clues initially for the team of researchers that were investigating the cause of the occurrence of rare blood clots, one of which was that there had been a greater amount of risk of blood clots in some of the vaccine technologies, and the other was that those people that had presented with the complaint of blood clots had some kind of usual antibodies in their bloodstream that was directly attaching a healthy protein in the body called platelet factor four.
The coronavirus vaccine that has been used in the United Kingdom all tried to insert a small part of the genetic code of the coronavirus inside the human body to gradually train the immune system. Some of the vaccines had packaged the genetic code inside a small sphere with a fatty outer layer, while the vaccine made by AstraZeneca had used adenovirus as the mode of transportation.
According to the researchers, the adenovirus might have some sort of connection with the formation of blood clots in rare cases. So, they utilized a technique which is known as cryo-electron microscopy, which helps them take images of the small adenovirus in details of microscopic nature.
The study, which has been published in the Science Advances journal, has revealed that the outer covering of the adenovirus is able to attract the protein of platelet factor four towards itself, similar to that of a magnet.
One of the researchers involved in the study said that they have been able to prove a probable link between the protein of platelet factor four and adenovirus, which results in the formation of blood clots. As the surface of adenovirus is extremely negative, while the exterior of the platelet factor four is of a positive nature, they are able to attract and fit together perfectly. This is the triggering factor, although multiple steps also occur after this stage, and the next stage of the research is thought to be misplaced immunity.